Article

Fish herpesvirus KLP manipulates Beclin1 to selectively degrade MITA through a precise autophagic manner for immune evasion

2022-11-09

Abstract excerpt

Control of host autophagy acceleration or attenuation has been confirmed in multiple terrestrial animal viruses. Little is known about such mechanisms in aquatic viruses. Here, we report a selective and ingenious autophagy modulation regulated by kinase-like protein (KLP) of cyprinid herpesvirus 2 (CyHV2) to restrict interferon (IFN) production by degrading IFN regulatory factor (IRF) 3 activation (MITA). First, e...

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Literature Corpus work: 2a70d18d-912b-5691-88bb-c09e7e6aa0ae
DOI: 10.1016/j.watbs.2022.100092

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