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Article

A new assay for functional screening of BRCA2 linker region mutations identifies variants that alter chemoresistance to cisplatin.

Experimental cell research - 10 Sept 2011

Warren Curtis R, Catts Zohra Ali-Khan, Farach-Carson Mary C

Abstract excerpt

Variants of unknown significance (VUS) complicate the assignment of risk to new DNA sequence variants found in at-risk populations. This study focused on the poorly studied linker region of the cancer-associated BRCA2 protein encoded by exons twelve through fourteen of BRCA2. To develop a new method to characterize VUS in this region of BRCA2, we first chose to study 4 reported VUS occurring on evolutionarily...

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Source

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Identifiers

PMID: 21741379
DOI: 10.1016/j.yexcr.2011.06.010
PMCID: PMC3173042

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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