Article
A genome-wide "pleiotropy scan" does not identify new susceptibility loci for estrogen receptor negative breast cancer.
PloS one - 1 Jan 2014
Campa Daniele, Barrdahl Myrto, Tsilidis Konstantinos K, Severi Gianluca, Diver W Ryan, Siddiq Afshan, Chanock Stephen, Hoover Robert N, Ziegler Regina G, Berg Christine D, Buys Saundra S, Haiman Christopher A, Henderson Brian E, Schumacher Fredrick R, Le Marchand Loïc, Flesch-Janys Dieter, Lindström Sara, Hunter David J, Hankinson Susan E, Willett Walter C, Kraft Peter, Cox David G, Khaw Kay-Tee, Tjønneland Anne, Dossus Laure, Trichopoulos Dimitrios, Panico Salvatore, van Gils Carla H, Weiderpass Elisabete, Barricarte Aurelio, Sund Malin, Gaudet Mia M, Giles Graham, Southey Melissa, Baglietto Laura, Chang-Claude Jenny, Kaaks Rudolf, Canzian Federico
Abstract excerpt
Approximately 15-30% of all breast cancer tumors are estrogen receptor negative (ER-). Compared with ER-positive (ER+) disease they have an earlier age at onset and worse prognosis. Despite the vast number of risk variants identified for numerous cancer types, only seven loci have been unambiguously identified for ER-negative breast cancer. With the aim of identifying new susceptibility SNPs for this disease we...
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