Article
Human TP53 polymorphism (rs1042522) modelled in mouse does not affect glucose metabolism and body composition.
Scientific reports - 13 Feb 2014
Reiling Erwin, Speksnijder Ewoud N, Pronk Amanda C M, van den Berg Sjoerd A A, Neggers Silvia J W, Rietbroek Ilma, van Steeg Harry, Dollé Martijn E T
Abstract excerpt
Variation in TP53 has been associated with cancer. The pro-allele of a TP53 polymorphism in codon 72 (rs1042522) has been associated with longevity. Recently, we showed that the same allele might be involved in preservation of glucose metabolism, body composition and blood pressure during ageing. Here, we assessed glucose tolerance and body composition in mice carrying the human polymorphism. Our data do not...
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