Article
Structure of a myosin•adaptor complex and pairing by cargo.
Proceedings of the National Academy of Sciences of the United States of America - 25 Mar 2014
Shi Hang, Singh Nimisha, Esselborn Filipp, Blobel Günter
Abstract excerpt
Myosin 4 protein (Myo4p), one of five distinct myosins of yeast, is dedicated to cytoplasmic transport of two types of cargos, zipcoded messenger ribonucleoprotein particles (mRNPs) and tubular endoplasmic reticulum (tER). Neither cargo binds directly to Myo4p. Instead, swi5p-dependent HO expression 3 protein (She3p) serves as an "adaptor" that contains three binding modules, one for Myo4p and one each for...
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