Article

Incorporating genetic selection into individual-based models (IBMs) of malaria and other infectious diseases

2019-10-30

Abstract excerpt

Optimal control strategies for human infections are often investigated by computational approaches using individual-based models (IBMs). These typically track humans and evaluate the impact of control interventions in terms of human deaths, clinical cases averted, interruption of transmission etc. Genetic selection can be incorporated into these IBMs and used to track the spread of mutations whose origin and sprea...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 67dd4222-6777-5bff-a57d-a2677a6f1420
DOI: 10.1101/819367

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Incorporating genetic selection into individual-based models (IBMs) of malaria and other infectious diseasesDOI 10.1101/819367Read

Mechanistic within-host models of the asexual <i>Plasmodium falciparum</i> infection: a review and analytical assessmentSemantic proximity Read

Investigating the drivers of the spatio-temporal patterns of genetic differences between Plasmodium falciparum malaria infections in Kilifi County, Kenya.Semantic proximity Read

Vector genetics, insecticide resistance and gene drives: An agent-based modeling approach to evaluate malaria transmission and eliminationSemantic proximity Read

Plasmodium falciparum population dynamics: only snapshots in time?Semantic proximity Read

Evaluating the performance of malaria genomics for inferring changes in transmission intensity using transmission modellingSemantic proximity Read

Simulating within-vector generation of the malaria parasite diversitySemantic proximity Read

Neutral vs. non-neutral genetic footprints of <i>Plasmodium falciparum</i> multiclonal infectionsSemantic proximity Read

Modelling pathogen load dynamics to elucidate mechanistic determinants of host–Plasmodium falciparum interactionsSemantic proximity Read

Unravelling complexities in human malaria transmission dynamics in Africa through a comprehensive knowledge of vector populationsSemantic proximity Read

MGDrivE 3: A decoupled vector-human framework for epidemiological simulation of mosquito genetic control tools and their surveillanceSemantic proximity Read

Targeting malaria parasites inside mosquitoes: ecoevolutionary consequencesSemantic proximity Read

EMOD with Full Parasite Genetics: A modeling framework for evaluating parasite genetic metrics for operational malaria molecular surveillanceSemantic proximity Read