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Article

Comparative RNAi screens in C. elegans and C. briggsae reveal the impact of developmental system drift on gene function.

PLoS genetics - 1 Feb 2014

Verster Adrian J, Ramani Arun K, McKay Sheldon J, Fraser Andrew G

Abstract excerpt

Although two related species may have extremely similar phenotypes, the genetic networks underpinning this conserved biology may have diverged substantially since they last shared a common ancestor. This is termed Developmental System Drift (DSD) and reflects the plasticity of genetic networks. One consequence of DSD is that some orthologous genes will have evolved different in vivo functions in two such...

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Identifiers

PMID: 24516395
DOI: 10.1371/journal.pgen.1004077
PMCID: PMC3916228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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