Article
Origin-specific epigenetic program correlates with vascular bed-specific differences in Rgs5 expression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2012
Zhang Hangjun, Gu Steven, Al-Sabeq Basil, Wang Sean, He Janet, Tam Alex, Cifelli Carlo, Mathalone Nurit, Tirgari Sam, Boyd Shelley, Heximer Scott P
Abstract excerpt
Cells from multiple origins contribute to vascular smooth muscle cell (VSMC) development. Phenotypic heterogeneity of VSMCs is associated with their point of developmental origin; however, the mechanisms driving such differences are unknown. We here examined the mechanisms controlling vascular bed-specific differences in Rgs5 expression during development. Rgs5 levels were similar across different regions of the...
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