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Article

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.

Nature medicine - 1 Aug 2016

Wang Wenzhang, Wang Luwen, Lu Junjie, Siedlak Sandra L, Fujioka Hisashi, Liang Jingjing, Jiang Sirui, Ma Xiaopin, Jiang Zhen, da Rocha Edroaldo Lummertz, Sheng Max, Choi Heewon, Lerou Paul H, Li Hu, Wang Xinglong

Abstract excerpt

Genetic mutations in TAR DNA-binding protein 43 (TARDBP, also known as TDP-43) cause amyotrophic lateral sclerosis (ALS), and an increase in the presence of TDP-43 (encoded by TARDBP) in the cytoplasm is a prominent histopathological feature of degenerating neurons in various neurodegenerative diseases. However, the molecular mechanisms by which TDP-43 contributes to ALS pathophysiology remain elusive. Here we...

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Identifiers

PMID: 27348499
DOI: 10.1038/nm.4130
PMCID: PMC4974139

Genes

TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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