Article
Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies.
PloS one - 1 Jan 2014
Osborn Daniel P S, Roccasecca Rosa Maria, McMurray Fiona, Hernandez-Hernandez Victor, Mukherjee Sriparna, Barroso Inês, Stemple Derek, Cox Roger, Beales Philip L, Christou-Savina Sonia
Abstract excerpt
Common intronic variants in the Human fat mass and obesity-associated gene (FTO) are found to be associated with an increased risk of obesity. Overexpression of FTO correlates with increased food intake and obesity, whilst loss-of-function results in lethality and severe developmental defects. Despite intense scientific discussions around the role of FTO in energy metabolism, the function of FTO during...
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