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Clinical pharmacology of tyrosine kinase inhibitors becoming generic drugs: the regulatory perspective

7 Feb 2014

Abstract excerpt

Over the last decades, billions have been spent and huge efforts have been taken in basic and clinical cancer research [CA Cancer J Clin63:11-30]. About a decade ago, the arms race between drugs and cancer cells reached a new level by introduction of tyrosine kinase inhibitors (TKI) into pharmacological anti-cancer therapy. According to their molecular mechanism of action, TKI in contrast to so-called "classic"...

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PMID: 24502453
DOI: 10.1186/1756-9966-33-15

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