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Article

Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway

1 Dec 2015

Abstract excerpt

Macroautophagy is an evolutionarily conserved cellular process involved in the clearance of proteins and organelles. Although the autophagy regulation machinery has been widely studied, the key epigenetic control of autophagy process still remains unknown. Here we report that the methyltransferase EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) epigenetically represses several negative regulators...

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Share to Autophagy in Disease and Therapy
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PMID: 26735435
DOI: 10.1080/15548627.2015.1117734

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