Article
Differential effects of methoxy group on the interaction of curcuminoids with two major ligand binding sites of human serum albumin.
PloS one - 1 Jan 2014
Sato Hiroki, Chuang Victor Tuan Giam, Yamasaki Keishi, Yamaotsu Noriyuki, Watanabe Hiroshi, Nagumo Kohei, Anraku Makoto, Kadowaki Daisuke, Ishima Yu, Hirono Shuichi, Otagiri Masaki, Maruyama Toru
Abstract excerpt
Curcuminoids are a group of compounds with a similar chemical backbone structure but containing different numbers of methoxy groups that have therapeutic potential due to their anti-inflammatory and anti-oxidant properties. They mainly bind to albumin in plasma. These findings influence their body disposition and biological activities. Spectroscopic analysis using site specific probes on human serum albumin (HSA)...
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