Article

In Search for the Low-Molecular-Weight Ligands of Human Serum Albumin that Affect its Affinity for Monomeric Amyloid β Peptide

2024-04-07

Abstract excerpt

An imbalance between production and excretion of amyloid β peptide (Aβ) in the brain tissues of Alzheimer’s disease (AD) patients leads to Aβ accumulation and formation of noxious Aβ oligomers/plaques. A promising approach to AD prevention is reduction of free Aβ level by directed enhancement of Aβ binding to its natural depot, human serum albumin (HSA). We previously demonstrated the ability of specific low-molec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f4506410-0aaf-55e3-b67e-319e9dd885dd
DOI: 10.20944/preprints202404.0469.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

In Search for the Low-Molecular-Weight Ligands of Human Serum Albumin that Affect its Affinity for Monomeric Amyloid β PeptideDOI 10.20944/preprints202404.0469.v1Read

Multifunctional Effect of Human Serum Albumin Reduces Alzheimer's Disease Related Pathologies in the 3xTg Mouse Model.Semantic proximity Read

Albumin domain mutants with enhanced Aβ binding capacity identified by phage display analysis for application in various peripheral Aβ elimination approaches of Alzheimer's disease treatment.Semantic proximity Read

Structural conservation and expanded functionality of hyper-stable human serum albumin variantsSemantic proximity Read

Aggregation-Dependent Epitope Sequence and Modification Fingerprints of Anti-Aβ AntibodiesSemantic proximity Read

Structure of Crenezumab Complex with Aβ Shows Loss of β-HairpinSemantic proximity Read

Mathematical Modeling of AA Amyloidosis: Coupling SAA-HDL Binding Dynamics with Path-Dependent Renal AgingSemantic proximity Read

Management of Hsp90-Dependent Protein Folding by Small Molecule Targeting the Aha1 Co-ChaperoneSemantic proximity Read

High-content affinity-based proteomics: unlocking protein biomarker discovery.Semantic proximity Read

Identification of an Allosteric Binding Site on Human Lysosomal Alpha-Galactosidase Opens the Way to New Pharmacological Chaperones for Fabry Disease.Semantic proximity Read

A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate.Semantic proximity Read

Mutants and molecular dockings reveal that the primary L-thyroxine binding site in human serum albumin is not the one which can cause familial dysalbuminemic hyperthyroxinemia.Semantic proximity Read

Structure-Guided Docking of Benzene-1,3-disulfonic Acid to the ApoE-HSPG Binding Site at Arginine 146 as a Christchurch-Mimetic Therapeutic Strategy for Alzheimer’s DiseaseSemantic proximity Read