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Article

Mitochondrial DNA 10609T promotes hypoxia-induced increase of intracellular ROS and is a risk factor of high altitude polycythemia.

PloS one - 1 Jan 2014

Jiang Chunhua, Cui Jianhua, Liu Fuyu, Gao Liang, Luo Yongjun, Li Peng, Guan Libin, Gao Yuqi

Abstract excerpt

Hypobaric hypoxia is the primary cause of high altitude polycythemia (HAPC). Mitochondria are critical organelles that consume high levels of oxygen and generate ATP. We hypothesize that the mitochondrion may be at the center of HAPC, and mitochondrial DNA (mtDNA) SNPs may be involved in its development. First, we conducted a case-control study to investigate the association of mtDNA variants with HAPC in Han...

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Identifiers

PMID: 24498190
DOI: 10.1371/journal.pone.0087775
PMCID: PMC3907523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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