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Article

Isolation, polarization, and expansion of CD4⁺ helper T cell lines and clones using magnetic beads.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014

Dahal Lekh N, Barker Robert N, Ward Frank J

Abstract excerpt

Autoreactive CD4⁺ helper T cells specific for a range of nucleoprotein-derived autoantigens are an important feature of systemic lupus erythematosus, driving B cell differentiation and autoantibody production and contributing to the inflammatory lesions caused by immune complex deposition. Several peptide epitopes from nucleoprotein antigens have been identified and offer a means selectively to manipulate T cell...

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PMID: 24497367
DOI: 10.1007/978-1-4939-0326-9_18

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