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Article

Estimating risks for variants of unknown significance according to their predicted pathogenicity classes with application to BRCA1.

Breast cancer research and treatment - 1 Feb 2014

Dowty J G, Lee E, McKean-Cowdin R, Henderson B E, Bernstein L, Ursin G, Hopper J L

Abstract excerpt

Sequence-based testing of disease-susceptibility genes has identified many variants of unknown significance (VUSs) whose pathogenicity is unknown at the time of their measurement. Female breast cancer cases aged 20-49 years at diagnosis and who have VUSs in BRCA1 and no mutations in BRCA2 have previously been identified through the population-based Los Angeles County Cancer Surveillance Program. These nominal...

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Source

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Identifiers

PMID: 24481681
DOI: 10.1007/s10549-014-2845-6
PMCID: PMC4059774

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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