Article
A closer look at the spectroscopic properties of possible reaction intermediates in wild-type and mutant (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase.
Biochemistry - 19 Jun 2012
Xu Weiya, Lees Nicholas S, Hall Dominique, Welideniya Dhanushi, Hoffman Brian M, Duin Evert C
Abstract excerpt
(E)-4-Hydroxy-3-methylbut-2-enyl diphosphate reductase (IspH or LytB) catalyzes the terminal step of the MEP/DOXP pathway where it converts (E)-4-hydroxy-3-methylbut-2-enyl diphosphate (HMBPP) into the two products, isopentenyl diphosphate and dimethylallyl diphosphate. The reaction involves the reductive elimination of the C4 hydroxyl group, using a total of two electrons. Here we show that the active form of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.