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Article

Bioorganometallic mechanism of action, and inhibition, of IspH.

Proceedings of the National Academy of Sciences of the United States of America - 9 Mar 2010

Wang Weixue, Wang Ke, Liu Yi-Liang, No Joo-Hwan, Li Jikun, Nilges Mark J, Oldfield Eric

Abstract excerpt

We have investigated the mechanism of action of Aquifex aeolicus IspH [E-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) reductase], together with its inhibition, using a combination of site-directed mutagenesis (K ( M ),V (max)), EPR and (1)H, (2)H, (13)C, (31)P, and (57)Fe-electron-nuclear do...

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Identifiers

PMID: 20173096
DOI: 10.1073/pnas.0911087107
PMCID: PMC2842026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20173096-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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