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Article

GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis

30 Jan 2014

Abstract excerpt

Abnormal Sonic Hedgehog signalling leads to increased transcriptional activation of its downstream effector, glioma 2 (GLI2), which is implicated in the pathogenesis of a variety of human cancers. However, the mechanisms underlying the tumorigenic role of GLI2 remain elusive. We demonstrate that overexpression of GLI2-β isoform, which lacks the N-terminal repressor domain (GLI2ΔN) in human keratinocytes is...

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PMID: 24481442
DOI: 10.1038/cddis.2013.535

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