Article
RHEB1 insufficiency in aged male mice is associated with stress-induced seizures.
GeroScience - 1 Dec 2017
Tian Qi, Gromov Pavel, Clement Joachim H, Wang Yingming, Riemann Marc, Weih Falk, Sun Xiao-Xin, Dai Mu-Shui, Fedorov Lev M
Abstract excerpt
The mechanistic target of rapamycin (mTOR), a protein kinase, is a central regulator of mammalian metabolism and physiology. Protein mTOR complex 1 (mTORC1) functions as a major sensor for the nutrient, energy, and redox state of a cell and is activated by ras homolog enriched in brain (RHEB1), a GTP-binding protein. Increased activation of mTORC1 pathway has been associated with developmental abnormalities,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.