Article
Non-CpG hypermethylation in placenta of mutation-induced intrauterine growth restricted bovine foetuses.
Biochemical and biophysical research communications - 14 Feb 2014
Venhoranta Heli, Li Shun, Salamon Sylwia, Flisikowska Tatiana, Andersson Magnus, Switonski Marek, Kind Alexander, Schnieke Angelika, Flisikowski Krzysztof
Abstract excerpt
The existence of non-CpG methylation in mammalian DNA has mainly been observed in embryonic stem cells, but its functional significance is uncertain. We found an age-dependent non-CpG hypermethylation in DMR at the 3' end of the MIMT1 in the placenta of intrauterine growth restricted foetuses in cattle. Data suggest that this DMR play a role in epigenetic regulation of the PEG3 domain.
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