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Article

Susceptibility to acute rheumatic fever based on differential expression of genes involved in cytotoxicity, chemotaxis, and apoptosis.

Infection and immunity - 1 Feb 2014

Bryant Penelope A, Smyth Gordon K, Gooding Travis, Oshlack Alicia, Harrington Zinta, Currie Bart, Carapetis Jonathan R, Robins-Browne Roy, Curtis Nigel

Abstract excerpt

It is unknown why only some individuals are susceptible to acute rheumatic fever (ARF). We investigated whether there are differences in the immune response, detectable by gene expression, between individuals who are susceptible to ARF and those who are not. Peripheral blood mononuclear cells (PBMCs) from 15 ARF-susceptible and 10 nonsusceptible (control) adults were stimulated with rheumatogenic (Rh+) group A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24478089
DOI: 10.1128/IAI.01152-13
PMCID: PMC3911372

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