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Article

Rheumatic fever: from innate to acquired immune response.

Annals of the New York Academy of Sciences - 1 Jun 2007

Guilherme L, Kalil J

Abstract excerpt

Rheumatic fever (RF) is triggered by S. pyogenes and affects 3-4% of untreated susceptible children. The immune response against streptococcal antigens can lead cross-recognition of heart tissue proteins resulting in rheumatic heart disease (RHD). HLA class II alleles have been associated with the development of RF/RHD. Tumor necrosis factor (TNF)-alpha is also located in the same chromosomal region of HLA genes...

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Source

Identifiers

PMID: 17804571
DOI: 10.1196/annals.1381.045

Genes

RHD
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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