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Analysis of pfhrp2 genetic diversity in Senegal and implications for use of rapid diagnostic tests

29 Jan 2014

Abstract excerpt

BACKGROUND: The Senegalese National Malaria Control Programme has recommended use of rapid diagnostic tests (RDTs) that target the histidine-rich protein 2 (HRP2), specific to Plasmodium falciparum, to diagnose malaria cases. The target antigen has been shown to be polymorphic, which may explain the variability in HRP2-based RDT results reported in field studies. The genetic diversity of the pfhrp2 gene has not...

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PMID: 24472178
DOI: 10.1186/1475-2875-13-34

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