TAK1 is a key regulator of oncogenic signaling and differentiation blockade in rhabdomyosarcoma

Abstract excerpt

Rhabdomyosarcoma (RMS) is a malignant soft tissue sarcoma with a skeletal muscle phenotype, accounting for approximately 50% of all pediatric soft tissue sarcomas and 8% of all childhood cancers. Although RMS cells express myogenic regulatory factors, they fail to undergo terminal differentiation into mature muscle cells. Transforming growth factor β-activated kinase 1 (TAK1) is a major signaling protein that acti...

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• Autophagy in Disease and Therapy
• CAR-T cell therapy research
• Forkhead Box Protein O1
• Forkhead Transcription Factors
• Hippo pathway signaling and YAP/TAZ
• Sarcoma Diagnosis and Treatment
• Single-cell and spatial transcriptomics
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

48549cc0-db55-502b-a7e9-8613f863e158

DOI

10.1101/2025.11.03.686399