Article
Brief report: etanercept inhibits the tumor necrosis factor α-driven shift of Th17 lymphocytes toward a nonclassic Th1 phenotype in juvenile idiopathic arthritis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 May 2014
Maggi Laura, Cimaz Rolando, Capone Manuela, Santarlasci Veronica, Querci Valentina, Simonini Gabriele, Nencini Francesca, Liotta Francesco, Romagnani Sergio, Maggi Enrico, Annunziato Francesco, Cosmi Lorenzo
Abstract excerpt
OBJECTIVE: To evaluate the effects of etanercept on the phenotype of CD4+ T helper lymphocytes from patients with juvenile idiopathic arthritis (JIA). METHODS: We compared the proportions of various Th cell subsets in peripheral blood (PB) from etanercept-treated and untreated JIA patients. An in vitro study was performed on PB mononuclear cells (PBMCs) from 15 children with untreated JIA, in which we evaluated...
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