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Article

An Asp7Gly substitution in PPARG is associated with decreased transcriptional activation activity.

PloS one - 1 Jan 2014

Hua Liushuai, Wang Jing, Li Mingxun, Sun Xiaomei, Zhang Liangzhi, Lei Chuzhao, Lan Xianyong, Fang Xingtang, Zhao Xin, Chen Hong

Abstract excerpt

As the master regulator of adipogenesis, peroxisome proliferator-activated receptor gamma (PPARG) is required for the accumulation of adipose tissue and hence contributes to obesity. A previous study showed that the substitution of +20A>G in PPARG changed the 7(th) amino acid from Asp to Gly, cre...

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Identifiers

PMID: 24466299
DOI: 10.1371/journal.pone.0086954
PMCID: PMC3900691

Genes

PPARG
CIDEC
DFFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24466299-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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