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Article

Checkpoint kinase 1 is negatively regulated by miR-497 in hepatocellular carcinoma

24 Jan 2014

Abstract excerpt

Checkpoint kinase 1 (CHEK1) is an evolutionarily conserved Ser/Thr kinase, which mediates cell-cycle arrest after DNA damage, and we previously reported that CHEK1 was overexpressed and associated with poor prognosis in hepatocellular carcinoma (HCC), indicating it was oncogenic gene. In this study, we aimed to elucidate the mechanism of CHEK1 overexpression in HCC. We first verified the upregulated CHEK1 by...

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PMID: 24464213
DOI: 10.1007/s12032-014-0844-4

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