Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expressional and functional characteristics of checkpoint kinase 1 as a prognostic biomarker in hepatocellular carcinoma

1 Dec 2022

Abstract excerpt

Background: Hepatocellular carcinoma (HCC) is the most common pathological subtype of liver cancer and is the third leading cause of cancer death worldwide. Checkpoint kinase 1 (CHEK1), an essential serine/threonine kinase that regulates the cell cycle, is reported to be associated with carcinogenesis. However, the biological role and clinical significance of CHEK1 in HCC are still incompletely known. Methods: In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36644193
DOI: 10.21037/tcr-22-1701

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expressional and functional characteristics of checkpoint kinase 1 as a prognostic biomarker in hepatocellular carcinomaPMID 36644193Read ↗

Checkpoint kinase 1 is negatively regulated by miR-497 in hepatocellular carcinomaSemantic proximity Read ↗

Gene Expression Alterations and Molecular Analysis of CHEK1 in Solid TumorsSemantic proximity Read ↗

Exploring the Prognostic Value and Biological Function of CPNE1 Gene in Hepatocellular CarcinomaSemantic proximity Read ↗

MELK is an oncogenic kinase essential for early hepatocellular carcinoma recurrence.Semantic proximity Read ↗

Identification of Key Genes and Prognostic Value Analysis in Hepatocellular Carcinoma by Integrated Bioinformatics AnalysisSemantic proximity Read ↗

Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular CarcinomaSemantic proximity Read ↗

Development and External Validation of a Novel Immune Checkpoint–Related Gene Signature for Prediction of Overall Survival in Hepatocellular CarcinomaSemantic proximity Read ↗

CEP72 Promotes Malignant Progression and Shapes the Tumor Immune Microenvironment in Hepatocellular Carcinoma: Integrated Multi-cohort Bioinformatics and In Vitro ValidationSemantic proximity Read ↗

Cell division cycle associated 8: A novel diagnostic and prognostic biomarker for hepatocellular carcinomaSemantic proximity Read ↗

Critical role of DEK and its regulation in tumorigenesis and metastasis of hepatocellular carcinomaSemantic proximity Read ↗

Bioinformatics analysis and experimental studies reveal KPNA2 as a novel biomarker of hepatocellular carcinoma progression and telomere maintenanceSemantic proximity Read ↗

The Expression of LIMK1 is Related to the Poor Prognosis and Immune Function of Hepatocellular CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.