Article
Genomics and disease progression in IgA nephritis.
Annals of the Academy of Medicine, Singapore - 1 Dec 2013
Woo Keng Thye, Lau Yeow Kok, Choong Hui Lin, Tan Han Khim, Foo Marjorie Wy, Lee Evan Jc, Anantharaman Vathsala, Lee Grace Sl, Yap Hui Kim, Yi Zhao, Fook-Chong Stephanie, Wong Kok Seng, Chan Choong Meng
Abstract excerpt
Apart from clinical, histological and biochemical indices, genomics are now being employed to unravel the pathogenetic mechanisms in the disease progression of IgA nephritis (IgAN). The results of angiotensin converting enzyme (ACE) gene polymorphism have been controversial. Those patients with the DD genotype seem to have a poorer prognosis. However, with high dose angiotensin receptor blocker (ARB) therapy, the...
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