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Article

Antioxidants and Quality of Aging: Further Evidences for a Major Role of TXNRD1 Gene Variability on Physical Performance at Old Age.

Oxidative medicine and cellular longevity - 1 Jan 2015

Dato Serena, De Rango Francesco, Crocco Paolina, Passarino Giuseppe, Rose Giuseppina

Abstract excerpt

Oxidative stress is a major determinant of human aging and common hallmark of age-related diseases. A protective role against free radicals accumulation was shown for thioredoxin reductase TrxR1, a key antioxidant selenoprotein. The variability of encoding gene (TXNRD1) was previously found associated with physical status at old age and extreme survival in a Danish cohort. To further investigate the influence of...

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Identifiers

PMID: 26064428
DOI: 10.1155/2015/926067
PMCID: PMC4429211

Genes

TXNRD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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