Article
Conformational changes induced by the A21G Flemish mutation in the amyloid precursor protein lead to increased Aβ production.
Structure (London, England : 1993) - 4 Mar 2014
Tang Tzu-Chun, Hu Yi, Kienlen-Campard Pascal, El Haylani Laetitia, Decock Marie, Van Hees Joanne, Fu Ziao, Octave Jean-Noel, Constantinescu Stefan N, Smith Steven O
Abstract excerpt
Proteolysis of the β C-terminal fragment (β-CTF) of the amyloid precursor protein generates the Aβ peptides associated with Alzheimer's disease. Familial mutations in the β-CTF, such as the A21G Flemish mutation, can increase Aβ secretion. We establish how the Flemish mutation alters the structure of C55, the first 55 residues of the β-CTF, using FTIR and solid-state NMR spectroscopy. We show that the A21G...
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