Article
Diversity of Prdm9 zinc finger array in wild mice unravels new facets of the evolutionary turnover of this coding minisatellite.
PloS one - 1 Jan 2014
Buard Jérôme, Rivals Eric, Dunoyer de Segonzac Denis, Garres Charlotte, Caminade Pierre, de Massy Bernard, Boursot Pierre
Abstract excerpt
In humans and mice, meiotic recombination events cluster into narrow hotspots whose genomic positions are defined by the PRDM9 protein via its DNA binding domain constituted of an array of zinc fingers (ZnFs). High polymorphism and rapid divergence of the Prdm9 gene ZnF domain appear to involve positive selection at DNA-recognition amino-acid positions, but the nature of the underlying evolutionary pressures...
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