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Article

Streptococcus pyogenes M1T1 Variants Induce an Inflammatory Neutrophil Phenotype Including Activation of Inflammatory Caspases.

Frontiers in cellular and infection microbiology - 1 Jan 2020

Williams Jonathan G, Ly Diane, Geraghty Nicholas J, McArthur Jason D, Vyas Heema K N, Gorman Jody, Tsatsaronis James A, Sluyter Ronald, Sanderson-Smith Martina L

Abstract excerpt

Invasive infections due to group A Streptococcus (GAS) advance rapidly causing tissue degradation and unregulated inflammation. Neutrophils are the primary immune cells that respond to GAS. The neutrophil response to GAS was characterised in response to two M1T1 isolates; 5448 and animal passaged variant 5448AP. Co-incubation of neutrophils with 5448AP resulted in proliferation of GAS and lowered the production...

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Identifiers

PMID: 33585270
DOI: 10.3389/fcimb.2020.596023
PMCID: PMC7876443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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