Article
A novel somatic FGFR3 mutation in primary lung cancer.
Oncology reports - 1 Mar 2014
Shinmura Kazuya, Kato Hisami, Matsuura Shun, Inoue Yusuke, Igarashi Hisaki, Nagura Kiyoko, Nakamura Satoki, Maruyama Kyoko, Tajima Mari, Funai Kazuhito, Ogawa Hiroshi, Tanahashi Masayuki, Niwa Hiroshi, Sugimura Haruhiko
Abstract excerpt
The recent discovery of mutations and fusions of oncokinase genes in a subset of lung cancers (LCs) is of considerable clinical interest, since LCs containing such mutations or fusion transcripts are reportedly sensitive to kinase inhibitors. To better understand the role of the recently identified fibroblast growth factor receptor 3 (FGFR3) mutations and fusions in pulmonary carcinogenesis, we examined 214 LCs...
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