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Article

Neonatal estradiol stimulation prevents epilepsy in Arx model of X-linked infantile spasms syndrome.

Science translational medicine - 22 Jan 2014

Olivetti Pedro R, Maheshwari Atul, Noebels Jeffrey L

Abstract excerpt

Infantile spasms are a catastrophic form of pediatric epilepsy with inadequate treatment. In patients, mutation of ARX, a transcription factor selectively expressed in neuronal precursors and adult inhibitory interneurons, impairs cell migration and causes a major inherited subtype of the disease X-linked infantile spasms syndrome. Using an animal model, the Arx((GCG)10+7) mouse, we determined that brief...

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Source

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Identifiers

PMID: 24452264
DOI: 10.1126/scitranslmed.3007231
PMCID: PMC4034383

Genes

ARX
GCG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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