Article
In situ dimerization of multiple wild type and mutant zinc transporters in live cells using bimolecular fluorescence complementation.
The Journal of biological chemistry - 14 Mar 2014
Lasry Inbal, Golan Yarden, Berman Bluma, Amram Noy, Glaser Fabian, Assaraf Yehuda G
Abstract excerpt
Zinc transporters (ZnTs) facilitate zinc efflux and zinc compartmentalization, thereby playing a key role in multiple physiological processes and pathological disorders, presumed to be modulated by transporter dimerization. We recently proposed that ZnT2 homodimerization is the underlying basis for the dominant negative effect of a novel heterozygous G87R mutation identified in women producing zinc-deficient...
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