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Article

Molecular dynamics simulation of the crystallizable fragment of IgG1-insights for the design of Fcabs.

International journal of molecular sciences - 2 Jan 2014

Lai Balder, Hasenhindl Christoph, Obinger Christian, Oostenbrink Chris

Abstract excerpt

An interesting format in the development of therapeutic monoclonal antibodies uses the crystallizable fragment of IgG1 as starting scaffold. Engineering of its structural loops allows generation of an antigen binding site. However, this might impair the molecule's conformational stability, which can be overcome by introducing stabilizing point mutations in the CH3 domains. These point mutations often affect the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24451126
DOI: 10.3390/ijms15010438
PMCID: PMC3907818

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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