Creating stable stem regions for loop elongation in Fcabs - insights from combining yeast surface display, in silico loop reconstruction and molecular dynamics simulations.

doi:10.1016/j.bbapap.2014.04.020

Article

Creating stable stem regions for loop elongation in Fcabs - insights from combining yeast surface display, in silico loop reconstruction and molecular dynamics simulations.

Biochimica et biophysica acta - 1 Sept 2014

Hasenhindl Christoph, Lai Balder, Delgado Javier, Traxlmayr Michael W, Stadlmayr Gerhard, Rüker Florian, Serrano Luis, Oostenbrink Chris, Obinger Christian

Abstract excerpt

Fcabs (Fc antigen binding) are crystallizable fragments of IgG where the C-terminal structural loops of the CH3 domain are engineered for antigen binding. For the design of libraries it is beneficial to know positions that will permit loop elongation to increase the potential interaction surface...

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Creating stable stem regions for loop elongation in Fcabs - insights from combining yeast surface display, in silico loop reconstruction and molecular dynamics simulations.

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