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Article

Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor.

Molecular and cellular biology - 1 Apr 2014

Adikesavan Anbu Karani, Karmakar Sudipan, Pardo Patricia, Wang Liguo, Liu Shuang, Li Wei, Smith Carolyn L

Abstract excerpt

The silencing mediator of retinoic acid and thyroid hormone receptors (SMRT) is an established histone deacetylase 3 (HDAC3)-dependent transcriptional corepressor. Microarray analyses of MCF-7 cells transfected with control or SMRT small interfering RNA revealed SMRT regulation of genes involved in DNA damage responses, and the levels of the DNA damage marker γH2AX as well as poly(ADP-ribose) polymerase cleavage...

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Source

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Identifiers

PMID: 24449765
DOI: 10.1128/MCB.01216-13
PMCID: PMC3993559

Genes

HDAC3
GPS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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