Article
Molecular pathogenesis of pancreatic cancer.
Hematology/oncology clinics of North America - 1 Feb 2002
Hilgers Werner, Rosty Christophe, Hahn Stephan A
Abstract excerpt
Our understanding of the biology of pancreatic carcinoma has greatly benefited from studies of the genetic alterations in this tumor type. The p16-CDK4-cyclinD-Rb pathway, the p53 tumor suppressor pathway, and the DPC4/Smad4 pathway are genetically inactivated in the majority of sporadic pancreatic carcinomas, whereas oncogenic K-ras signaling is almost ubiquitously activated. These genetic data have provided the...
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