Article
Lack of functional caveolae in Cav3 mutated human dystrophic myotubes results in deficient mechanoprotection and IL6/STAT3 mechanosignaling
2018-03-20
Abstract excerpt
Caveolin-3 is the major structural protein of caveolae in muscle cells. Mutations in the CAV3 gene cause different type of muscle disorders mostly characterized by defects in membrane integrity and repair, deregulation in the expression of various muscle proteins and deregulation of several muscle associated signaling pathways. We show here that myotubes derived from patients bearing the CAV3 P28L and R26Q mutat...
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Identifiers and source
- Literature Corpus work
- 253aafbb-7251-55e8-aa1a-583f859e7482
- DOI
- 10.1101/281113