Article
Integrated genome-wide genotyping and gene expression profiling reveals BCL11B as a putative oncogene in acute myeloid leukemia with 14q32 aberrations.
Haematologica - 1 May 2014
Abbas Saman, Sanders Mathijs A, Zeilemaker Annelieke, Geertsma-Kleinekoort Wendy M C, Koenders Jasper E, Kavelaars Francois G, Abbas Zabiollah G, Mahamoud Souad, Chu Isabel W T, Hoogenboezem Remco, Peeters Justine K, van Drunen Ellen, van Galen Janneke, Beverloo H Berna, Löwenberg Bob, Valk Peter J M
Abstract excerpt
Acute myeloid leukemia is a neoplasm characterized by recurrent molecular aberrations traditionally demonstrated by cytogenetic analyses. We used high density genome-wide genotyping and gene expression profiling to reveal acquired cryptic abnormalities in acute myeloid leukemia. By genome-wide genotyping of 137 cases of primary acute myeloid leukemia, we disclosed a recurrent focal amplification on chromosome...
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