Article
Plus ça change - evolutionary sequence divergence predicts protein subcellular localization signals.
BMC genomics - 20 Jan 2014
Fukasawa Yoshinori, Leung Ross K K, Tsui Stephen K W, Horton Paul
Abstract excerpt
BACKGROUND: Protein subcellular localization is a central problem in understanding cell biology and has been the focus of intense research. In order to predict localization from amino acid sequence a myriad of features have been tried: including amino acid composition, sequence similarity, the presence of certain motifs or domains, and many others. Surprisingly, sequence conservation of sorting motifs has not yet...
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