Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas.

Science (New York, N.Y.) - 17 Jan 2014

Schramek Daniel, Sendoel Ataman, Segal Jeremy P, Beronja Slobodan, Heller Evan, Oristian Daniel, Reva Boris, Fuchs Elaine

Abstract excerpt

Mining modern genomics for cancer therapies is predicated on weeding out "bystander" alterations (nonconsequential mutations) and identifying "driver" mutations responsible for tumorigenesis and/or metastasis. We used a direct in vivo RNA interference (RNAi) strategy to screen for genes that upon repression predispose mice to squamous cell carcinomas (SCCs). Seven of our top hits-including Myh9, which encodes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Molecular Motor Proteins

Share to Myosin Heavy Chains

Share to RNA Interference

Share to Tumor Suppressor Protein p53

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24436421
DOI: 10.1126/science.1248627
PMCID: PMC4159249

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas.PMID 24436421Read ↗

Conditional deletion of nonmuscle myosin II-A in mouse tongue epithelium results in squamous cell carcinoma.Semantic proximity Read ↗

Non-Muscle Myosin II A: Friend or Foe in Cancer?Semantic proximity Read ↗

Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos.Semantic proximity Read ↗

Non‐muscle myosins in tumor progression, cancer cell invasion, and metastasisSemantic proximity Read ↗

MYH9-siRNA and MYH9 mutant alleles: expression in cultured cell lines and their effects upon cell structure and function.Semantic proximity Read ↗

Unconventional myosin VIIA promotes melanoma progression.Semantic proximity Read ↗

MYH9: A key protein involved in tumor progression and virus-related diseases.Semantic proximity Read ↗

An MYH9 human disease model in flies: site-directed mutagenesis of the Drosophila non-muscle myosin II results in hypomorphic alleles with dominant character.Semantic proximity Read ↗

The Motor Protein KIF14 Inhibits Tumor Growth and Cancer Metastasis in Lung AdenocarcinomaSemantic proximity Read ↗

Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis.Semantic proximity Read ↗

RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemiaSemantic proximity Read ↗

MYH9 promotes cell metastasis via inducing Angiogenesis and Epithelial Mesenchymal Transition in Esophageal Squamous Cell Carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.