Article
Genetics and genomics of pulmonary arterial hypertension.
Journal of the American College of Cardiology - 24 Dec 2013
Soubrier Florent, Chung Wendy K, Machado Rajiv, Grünig Ekkehard, Aldred Micheala, Geraci Mark, Loyd James E, Elliott C Gregory, Trembath Richard C, Newman John H, Humbert Marc
Abstract excerpt
Major discoveries have been obtained within the last decade in the field of hereditary predisposition to pulmonary arterial hypertension (PAH). Among them, the identification of bone morphogenetic protein receptor type 2 (BMPR2) as the major predisposing gene and activin A receptor type II-like kinase-1 (ACVRL1, also known as ALK1) as the major gene when PAH is associated with hereditary hemorrhagic...
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