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Article

Helicase–Primase Inhibitor Pritelivir for HSV-2 Infection

15 Jan 2014

Abstract excerpt

BACKGROUND: Pritelivir, an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. We tested the efficacy and safety of pritelivir in otherwise healthy persons with genital HSV-2 infection. METHODS: We randomly assigned 156 HSV-2-positive persons with a history of genital herpes to receive one of four doses of oral...

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PMID: 24428466
DOI: 10.1056/nejmoa1301150

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