Article

Limitations of acyclovir and identification of potent HSV antivirals using 3D bioprinted human skin equivalents

2024-12-09

Abstract excerpt

Herpes simplex virus (HSV) infection has worldwide public health concerns and lifelong medical impacts. The standard therapy, acyclovir, has limited efficacy in preventing HSV subclinical virus shedding, and drug resistance occurs in immunocompromised patients, highlighting the need for novel therapeutics. HSV manifests in the skin and mucosal epithelium. Here, we found acyclovir significantly less effective in sk...

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Literature Corpus work: 22611bdc-fa5a-5d31-9c55-eb3a64e026d9
DOI: 10.1101/2024.12.04.626896

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