Article
Hepatitis B virus infection enhances susceptibility toward adeno-associated viral vector transduction in vitro and in vivo.
Hepatology (Baltimore, Md.) - 1 Jun 2014
Hösel Marianna, Lucifora Julie, Michler Thomas, Holz Gisela, Gruffaz Marion, Stahnke Stephanie, Zoulim Fabien, Durantel David, Heikenwalder Mathias, Nierhoff Dirk, Millet Rachel, Salvetti Anna, Protzer Ulrike, Büning Hildegard
Abstract excerpt
UNLABELLED: Gene therapy has become an accepted concept for the treatment of a variety of different diseases. In contrast to preclinical models, subjects enrolled in clinical trials, including gene therapy, possess a history of infection with microbes that may influence its safety and efficacy. Especially, viruses that establish chronic infections in the liver, one of the main targets for in vivo gene therapy,...
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